anticlimax

'The rate at which tolerance develops and the kind and severity of withdrawal symptoms vary with individuals and circumstances, but they include, in the four to six hours after the last dose, frequent yawning, sneezing, runny nose, goose bumps and, from the twelfth hour to the third day, violent diarrhoea, alternating chills and sweats, hypersensitivity to touch, irritability, depression and spontaneous orgasms.'

Milligan, Appendix in De Quincey's Confessions of an English Opium Eater